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Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Prognosis

Medically reviewed by Todd Gersten, M.D.
Written by Maureen McNulty
Posted on February 2, 2022

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are two related blood cancers. CLL leads to cancer cells in the blood and bone marrow (the spongy tissue found inside certain bones). SLL causes tumors in the lymph nodes (structures that help fight infection and filter out waste from the body). People can live with these two similar slow-growing diseases for many years.

Small Lymphocytic Lymphoma Survival Rates

Researchers estimate how long people with SLL live using statistics called survival rates. You may do better or worse than these predicted rates depending on whether you have certain prognostic factors that raise or lower your risk of severe disease.

The five-year survival rate for SLL in the United States is 86.9 percent. This means that, for every 100 people diagnosed with SLL now, about 87 people are expected to be alive in five years. This survival rate also applies to people with CLL.

Treatment options for SLL are constantly improving. Because the five-year survival rate is based on past information, it may not reflect newer, better methods. People being diagnosed with CLL now may have an even better prognosis than is reflected in these statistics.

Prognostic Factors for SLL

Survival rates don’t tell you what your outcome will be. They are estimates based on large numbers of people. Your individual outlook depends on your prognostic factors — characteristics of you or your disease that increase or decrease your chance of having a good outlook. Talk to your doctor to learn more about how your personal factors affect your prognosis.

Age

Younger people tend to have a better prognosis when they are diagnosed with SLL or CLL:

  • People under the age of 55 are 94 percent as likely to live at least five years, compared to those without SLL.
  • Those between the ages of 55 and 64 are 92 percent as likely to live for five years or more.
  • People who are 65 years old or older are 83 percent as likely to live at least five years.

Older adults often have a worse outlook because they can’t undergo certain therapies. Some cancer treatments lead to better outcomes for young people but cause too many side effects in older people.

Lymphoma Stage

One of the factors in determining SLL outlook is the lymphoma stage. The stage describes where in the body lymphoma cells can be found and whether these cells have spread.

Doctors often stage SLL using the Lugano system, although they may also use Rai or Binet staging systems if SLL affects the blood or bone marrow. Under the Lugano system, the higher the stage is, the more advanced the lymphoma and the farther cancer cells have spread:

  • Stage 1 — Lymphoma is found in one group of lymph nodes or in one small part of an organ.
  • Stage 2 — Lymphoma cells are located in multiple groups of lymph nodes in both the top and bottom halves of the body. Alternatively, cancer cells are found in a single group of lymph nodes and one nearby organ.
  • Stage 3 — The lymphoma has spread to groups of lymph nodes on both halves of the body. People are also diagnosed with stage 3 if lymphoma cells are found in the top half of the body plus the spleen.
  • Stage 4 — There are lymphoma cells found throughout one or more organs that are not a part of the lymphatic system, including the lungs or liver.

Advanced-stage SLL is more likely to lead to a poor prognosis. People with stage 3 or stage 4 SLL need more aggressive treatments than those with early-stage disease.

Gene Mutations and Chromosome Changes

Cancer develops when a cell’s genes become damaged and undergo changes. Doctors can find gene changes in more than 80 percent of people with SLL and CLL. Some of these changes lead to more aggressive leukemia, and others are linked to slower-growing SLL.

Some people with SLL have mutations in a gene called immunoglobulin heavy chain variable region (IGHV). People with mutations often have a better outlook — treatment is more effective, and they have longer survival rates. IGHV mutations also affect how likely a person is to experience complete remission or the absence of disease signs and symptoms. In one study, 82 percent of people with mutated IGHV were in complete remission after six years. However, only 47 percent of people with normal IGHV were in complete remission at this time.

Additional gene mutations are also linked with a poor prognosis. People with changes in the TP53, NOTCH1, ATM, BIRC3, and SF3B1 genes are more likely to be resistant to treatment. Some studies have found that these changes can lead to worse outcomes, although this is still being studied.

Cytogenetic tests can show chromosome changes. Chromosomes are large pieces of DNA that contain genes. Sometimes, chromosomes within cancer cells contain deletions. Some of these abnormalities serve as prognostic factors in SLL. Changes called del(17p) and del(11q) — deletions in chromosomes 17 or 11 — are linked with a worse prognosis. On the other hand, deletion of part of chromosome 13 can be a sign of a favorable prognosis.

Newer SLL/CLL treatments may be more effective at treating people with SLL who have some of these high-risk gene changes. For example, the targeted therapy drug Imbruvica (ibrutinib) is effective at treating lymphoma and leukemia cells that contain del(17p) and del(11q).

Proteins on the Lymphoma Cell Surface

Gene changes within cancer cells sometimes cause these cells to have different proteins on their outer surface. A person with SLL may have a worse prognosis if many of their lymphoma cells contain the proteins ZAP-70 or CD38. These proteins can be “read” with a test called flow cytometry.

Proteins in the Blood

Doctors may use blood tests to measure the levels of certain proteins. High levels of a protein called beta-2 microglobulin can indicate a poor prognosis.

How Quickly Lymphoma Cells Grow

As a person’s lymphoma is treated and monitored, doctors will measure levels of cancerous lymphocytes (white blood cells). If lymphocytes grow slowly, this may be a sign that the SLL will lead to a better prognosis. However, rapidly rising lymphocyte levels often signal more aggressive disease. A person may have a worse prognosis if their lymphocyte count doubles in less than a year.

Lymphocyte Levels

Blood tests show that some people with SLL have high levels of certain types of lymphocytes, such as prolymphocytes. People with these cells are more likely to have their SLL transform into another more severe type of cancer such as prolymphocytic leukemia or diffuse large B-cell lymphoma.

Determining Individual Prognosis

Doctors sometimes predict outcomes for SLL and CLL with a tool called the CLL International Prognostic Index (CLL-IPI). The CLL-IPI takes into account individual risk factors and divides people with SLL into four risk groups. The prognostic index considers age, stage, changes in the TP53 and IGHV genes and levels of beta-2-microglobulin. Each of these prognostic factors is given a certain number of points, and then the points are added up into one final score. This calculation leads to the following groups:

  • Low-risk — 93.2 percent of people in this group live for at least five years.
  • Intermediate-risk — 79.3 percent of people live for at least five years.
  • High-risk — 63.3 percent of people live for at least five years.
  • Very high-risk — 23.3 percent of people live for at least five years.

These risk groups give you a clue about not only your prognosis but also about what treatment options may be best. People in the lowest-risk group may not need any treatment at all, whereas people in the highest-risk group may want to try newer therapies or take part in clinical trials.

Talk With Others Who Understand

MyLymphomaTeam is the social network for people with lymphoma. On MyLymphomaTeam, more than 10,000 members come together to ask questions, give advice, and share their stories with others who understand life with lymphoma.

Are you living with small lymphocytic lymphoma? Share your experiences in the comments below, or start a conversation by posting on MyLymphomaTeam.

References
  1. CLL/SLL — National Cancer Institute
  2. Cancer Stat Facts: NHL— Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) — National Cancer Institute Surveillance, Epidemiology and End Results Program
  3. Trends in Survival of Chronic Lymphocytic Leukemia Patients in Germany and the USA in the First Decade of the Twenty-First Century — Journal of Hematology & Oncology
  4. Leukemia — Chronic Lymphocytic — CLL: Statistics — American Society of Clinical Oncology
  5. Prognostic Factor — National Cancer Institute
  6. Non-Hodgkin Lymphoma Stages — American Cancer Society
  7. Changes in Genes — American Cancer Society
  8. Chronic Lymphocytic Leukemia: An Overview of Diagnosis, Prognosis, and Treatment — American Journal of Managed Care
  9. Why Is the Immunoglobulin Heavy Chain Gene Mutation Status a Prognostic Indicator in Chronic Lymphocytic Leukemia? — Acta Haematologica
  10. Relevance of the Immunoglobulin VH Somatic Mutation Status in Patients With Chronic Lymphocytic Leukemia Treated With Fludarabine, Cyclophosphamide, and Rituximab (FCR) or Related Chemoimmunotherapy Regimens — Blood
  11. TP53 Aberrations in Chronic Lymphocytic Leukemia: An Overview of the Clinical Implications of Improved Diagnostics — Haematologica
  12. Clinical and Laboratory Prognostic Indicators in Chronic Lymphocytic Leukemia — Cancer Control
  13. How Is Chronic Lymphocytic Leukemia Staged? — American Cancer Society
  14. Extended Follow-Up and Impact of High-Risk Prognostic Factors From the Phase 3 RESONATE Study in Patients With Previously Treated CLL/SLL — Leukemia
  15. Chronic Lymphocytic Leukemia: 2020 Update on Diagnosis, Risk Stratification and Treatment — American Journal of Hematology
Posted on February 2, 2022

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Todd Gersten, M.D. is a hematologist-oncologist at the Florida Cancer Specialists & Research Institute in Wellington, Florida. Review provided by VeriMed Healthcare Network. Learn more about him here.
Maureen McNulty studied molecular genetics and English at Ohio State University. Learn more about her here.

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