Frank4,
Hi! And welcome to the site. Everyone on here is so kind, supportive and helpful. I have/had DLBCL stage IV also. I too had RCHOP chemo. 6 treatments. During my treatments I felt sick the evening of my treatments. Not so good the next day either. But, then it started to lift some. Probably the first 3 days I didn't feel like myself. Tired, nausea etc. The first week was a bit rough, the second week I was much better, the third week even better. Then it was time for my next treatment. I had them every 3 weeks. As the treatments went on they did get rougher also. I've heard it's an accumulated situation. Make sure you drink LOTS of fluids. I drank alot even during my treatments to flush it through. Try to eat. Especially protein. I ate peanut butter bagels even when I didn't feel like it. My husband made me smoothies too with ice-cream, fruit and kale. Anything to keep up your strength. I rested alot too. Watched alot of cowboy movies!! But, I've been in remission now for 2 1/2 yrs. I cut out sugar, coffee and soda. I now drink green tea, water and naked juice only. (You can get that at your local grocery store) I walk daily too. Good luck to you on your treatments and if you have any questions please feel free to ask me. Kelly

Good to hear these responses from people. I was diagnosed 3 days ago. I’m 75 years old and have received a heart transplant 20 years ago.
I’m suppose to be starting treatments in the next 2 weeks or so. Just trying to see what to expect

First 2 were ok. Nausea kicked in at times and tabs helped me to subside. I walked each and every day, even on the day of treatments. Yes, tired. Make sure you drink 2 Liters of water or other fluid. I am diabetic, so fruit juices are out but I take fruits. Due to meds (I forgot), my blood sugar shoots up for 1 wk and had to manage with insulin. Fun days :) Meditation, prayers helped, reading helped. That walking helped me literally to get through the cycles. Now I am free with 3 years.

Good luck! I admire anyone who tries to work through treatment. I had R-CHOP from October to January last winter. I found the first 5 days to be tolerable, but the fatigue really set in days 6-12. The last week was OK. So I would say give yourself some grace for the first 2 weeks--do as much as you can without exhausting yourself. Stay hopeful. Take whatever nausea drugs and laxatives they allow. Drink a lot. Just give yourself a break if you need it. It's not easy, but it's not the worst thing in the world, and the 4 months will go quickly.

Thanks for the detailed response. I’ll try to post real time reactions once I’m home after the first treatment on Monday.